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  • 1
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    Distinct fibroblast lineages determine dermal architecture in skin development and repair (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-12-18
    Description: Fibroblasts are the major mesenchymal cell type in connective tissue and deposit the collagen and elastic fibres of the extracellular matrix (ECM). Even within a single tissue, fibroblasts exhibit considerable functional diversity, but it is not known whether this reflects the existence of a differentiation hierarchy or is a response to different environmental factors. Here we show, using transplantation assays and lineage tracing in mice, that the fibroblasts of skin connective tissue arise from two distinct lineages. One forms the upper dermis, including the dermal papilla that regulates hair growth and the arrector pili muscle, which controls piloerection. The other forms the lower dermis, including the reticular fibroblasts that synthesize the bulk of the fibrillar ECM, and the preadipocytes and adipocytes of the hypodermis. The upper lineage is required for hair follicle formation. In wounded adult skin, the initial wave of dermal repair is mediated by the lower lineage and upper dermal fibroblasts are recruited only during re-epithelialization. Epidermal beta-catenin activation stimulates the expansion of the upper dermal lineage, rendering wounds permissive for hair follicle formation. Our findings explain why wounding is linked to formation of ECM-rich scar tissue that lacks hair follicles. They also form a platform for discovering fibroblast lineages in other tissues and for examining fibroblast changes in ageing and disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868929/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868929/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Driskell, Ryan R -- Lichtenberger, Beate M -- Hoste, Esther -- Kretzschmar, Kai -- Simons, Ben D -- Charalambous, Marika -- Ferron, Sacri R -- Herault, Yann -- Pavlovic, Guillaume -- Ferguson-Smith, Anne C -- Watt, Fiona M -- 079249/Wellcome Trust/United Kingdom -- 092096/Wellcome Trust/United Kingdom -- 095606/Wellcome Trust/United Kingdom -- 096540/Wellcome Trust/United Kingdom -- 098357/Wellcome Trust/United Kingdom -- G0600796/Medical Research Council/United Kingdom -- Department of Health/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2013 Dec 12;504(7479):277-81. doi: 10.1038/nature12783.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK [2] Centre for Stem Cells and Regenerative Medicine, King's College London, 28th floor, Tower Wing, Guy's Hospital, London SE1 9RT, UK. ; 1] Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK [2] Centre for Stem Cells and Regenerative Medicine, King's College London, 28th floor, Tower Wing, Guy's Hospital, London SE1 9RT, UK [3]. ; 1] Centre for Stem Cells and Regenerative Medicine, King's College London, 28th floor, Tower Wing, Guy's Hospital, London SE1 9RT, UK [2] Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK [3]. ; Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK. ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK. ; Institut Clinique de la Souris, Parc d'Innovation, 67404 Illkrich-Graffenstaden, Cedex, France. ; Centre for Stem Cells and Regenerative Medicine, King's College London, 28th floor, Tower Wing, Guy's Hospital, London SE1 9RT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24336287" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/cytology/metabolism ; Animals ; *Cell Lineage ; Dermis/anatomy & histology/cytology/embryology/growth & development ; Female ; Fibroblasts/*cytology/transplantation ; Hair Follicle/cytology/metabolism ; In Vitro Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Muscle, Smooth/cytology/metabolism ; Skin/anatomy & histology/*cytology/embryology/*growth & development ; Wound Healing/*physiology ; beta Catenin/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-07-22
    Description: The gene for the atypical NOTCH ligand delta-like homologue 1 (Dlk1) encodes membrane-bound and secreted isoforms that function in several developmental processes in vitro and in vivo. Dlk1, a member of a cluster of imprinted genes, is expressed from the paternally inherited chromosome. Here we show that mice that are deficient in Dlk1 have defects in postnatal neurogenesis in the subventricular zone: a developmental continuum that results in depletion of mature neurons in the olfactory bulb. We show that DLK1 is secreted by niche astrocytes, whereas its membrane-bound isoform is present in neural stem cells (NSCs) and is required for the inductive effect of secreted DLK1 on self-renewal. Notably, we find that there is a requirement for Dlk1 to be expressed from both maternally and paternally inherited chromosomes. Selective absence of Dlk1 imprinting in both NSCs and niche astrocytes is associated with postnatal acquisition of DNA methylation at the germ-line-derived imprinting control region. The results emphasize molecular relationships between NSCs and the niche astrocyte cells of the microenvironment, identifying a signalling system encoded by a single gene that functions coordinately in both cell types. The modulation of genomic imprinting in a stem-cell environment adds a new level of epigenetic regulation to the establishment and maintenance of the niche, raising wider questions about the adaptability, function and evolution of imprinting in specific developmental contexts.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160481/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160481/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferron, Sacri R -- Charalambous, Marika -- Radford, Elizabeth -- McEwen, Kirsten -- Wildner, Hendrik -- Hind, Eleanor -- Morante-Redolat, Jose Manuel -- Laborda, Jorge -- Guillemot, Francois -- Bauer, Steven R -- Farinas, Isabel -- Ferguson-Smith, Anne C -- G0701196/Medical Research Council/United Kingdom -- G0701196(84685)/Medical Research Council/United Kingdom -- G0800784/Medical Research Council/United Kingdom -- MC_U117570528/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2011 Jul 20;475(7356):381-5. doi: 10.1038/nature10229.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21776083" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/genetics ; Animals ; Animals, Newborn/*metabolism ; Astrocytes/*metabolism/secretion ; Base Sequence ; Cell Membrane/metabolism ; Cells, Cultured ; Embryo, Mammalian/embryology/metabolism ; Female ; *Genomic Imprinting ; Genotype ; Intercellular Signaling Peptides and ; Proteins/deficiency/genetics/*metabolism/secretion ; Male ; Mice ; Mice, Inbred C57BL ; Neural Stem Cells/*metabolism ; *Neurogenesis ; Olfactory Bulb/cytology ; Protein Isoforms/genetics/metabolism/secretion ; Stem Cell Niche/*cytology/secretion
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
    Electronic Resource
    Electronic Resource
    A very sensitive microcalorimetry technique for measuring specific heat of μg single crystals (1997)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 1501-1509 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A microcalorimetry technique allowing one to measure the specific heat of bulk single crystals of a mass typically 10 μg, with a relative resolution Δc/c of 10−4 is presented. The well known ac steady state technique is employed. The sample holder is a polymer membrane with lithographically patterned thermometer and heaters made out of metallic thin films. The diameter of the useful area is 0.6 mm and the specific heat of the addendum is 1.5 μJ/K at 100 K. The sample is thermally coupled to the membrane through a gold thin film sputtered on its surface. The thermal coupling time constant of the sample is ∼5 ms, allowing to work at frequencies of 10 Hz. The method was applied to small single crystals of YBCO, providing the specific heat jump at the superconducting transition with a relative resolution of 10−2 and a precision of 10−1. The method is optimized at the temperature range 40–160 K, but can easily be modified for lower temperatures. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1147938
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  • 4
    Electronic Resource
    Electronic Resource
    Nonperturbative ion etching of YBaCuO thin films (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 1219-1221 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Conventional Ar ion etching deteriorates the features of YBaCuO superconducting thin films, because of heating and ion damage. We demonstrate here the interest of two other approaches: Ar ion etching with liquid nitrogen cooling and Xe ion etching.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.356459
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  • 5
    Electronic Resource
    Electronic Resource
    First direct measurement of the C-Axis resistivity in superconducting single crystals Y"1Ba"2Cu"3O"7"-"x
    Amsterdam : Elsevier
    Physica B: Physics of Condensed Matter 169 (1991), S. 637-638 
    Details
    ISSN: 0921-4526
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4526(91)90364-K
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  • 6
    Electronic Resource
    Electronic Resource
    Flux lattice melting in YBCO
    Amsterdam : Elsevier
    Physica C: Superconductivity and its applications 235-240 (1994), S. 45-48 
    Details
    ISSN: 0921-4534
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4534(94)91310-2
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  • 7
    Electronic Resource
    Electronic Resource
    Genetic variation in male song and female song preference in the grasshopper Chorthippus brunneus (Orthoptera: Acrididae)
    Amsterdam : Elsevier
    Animal Behaviour 47 (1994), S. 399-411 
    Details
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/anbe.1994.1054
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  • 8
    Electronic Resource
    Electronic Resource
    Strong Nearness Frames Having Enough Cauchy Filters (2000)
    Springer
    Applied categorical structures 8 (2000), S. 639-648 
    Details
    ISSN: 1572-9095
    Keywords: sums and direct limits of frames ; uniform frames ; strong nearness frames ; Cauchy filters ; Cauchy points
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We prove results establishing sufficient conditions for the sum of two nearness frames to have enough Cauchy filters. From these results and the fact that, in the category of strong nearness frames having enough Cauchy filters and uniform frame maps, complete spatial frames form a coreflective subcategory, follow a variety of results where the open-sets contravariant functor Ω from topological spaces to frames transforms products into sums and inverse limits into direct limits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008681506290
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  • 9
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    Asymmetry of Critical Exponents inYBa2Cu3O7−δ (1999)
    American Physical Society
    Details
    Publication Date: 1999-09-06
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society
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  • 10
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    Subpicovolt Resolution Measurements of the Current-Voltage Characteristics of Twinned CrystallineYBa2Cu3O7−x: New Evidence for a Vortex-Glass Phase (1995)
    American Physical Society
    Details
    Publication Date: 1995-09-25
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society
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