Publication Date:
1995-07-07
Description:
In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag-related gene (HERG) has now been shown to encode an inwardly rectifying potassium channel. The properties of HERG channels are consistent with the gating properties of Eag-related and other outwardly rectifying, S4-containing potassium channels, but with the addition of an inactivation mechanism that attenuates potassium efflux during depolarization. Because mutations in HERG cause a form of long-QT syndrome, these properties of HERG channel function may be critical to the maintenance of normal cardiac rhythmicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trudeau, M C -- Warmke, J W -- Ganetzky, B -- Robertson, G A -- New York, N.Y. -- Science. 1995 Jul 7;269(5220):92-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Wisconsin Medical School, Madison 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604285" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Barium/pharmacology
;
Cesium/pharmacology
;
Ether-A-Go-Go Potassium Channels
;
Humans
;
*Ion Channel Gating
;
Long QT Syndrome/genetics/physiopathology
;
Membrane Potentials
;
Mutation
;
Oocytes
;
Patch-Clamp Techniques
;
Potassium Channels/drug effects/genetics/*physiology
;
*Potassium Channels, Inwardly Rectifying
;
Ranidae
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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