Publication Date:
1981-05-22
Description:
Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baudry, M -- Bundman, M C -- Smith, E K -- Lynch, G S -- MH-19793-09/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 May 22;212(4497):937-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015504" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium/antagonists & inhibitors/*pharmacology
;
Cerebellum/metabolism
;
Cerebral Cortex/metabolism
;
Cysteine Endopeptidases
;
Endopeptidases/*metabolism
;
Glutamates/*metabolism
;
Leupeptins/pharmacology
;
Membrane Proteins/*metabolism
;
Molecular Weight
;
Rats
;
Synaptic Membranes/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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