Publication Date:
2004-07-03
Description:
Organelle inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G2-to-prophase transition of the cell cycle, and hence cell division.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hidalgo Carcedo, Cristina -- Bonazzi, Matteo -- Spano, Stefania -- Turacchio, Gabriele -- Colanzi, Antonino -- Luini, Alberto -- Corda, Daniela -- E.0982/Telethon/Italy -- New York, N.Y. -- Science. 2004 Jul 2;305(5680):93-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15232108" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carrier Proteins/chemistry/genetics/*metabolism
;
Cell Line
;
Cytosol
;
G2 Phase
;
Golgi Apparatus/*physiology/ultrastructure
;
Interphase
;
Intracellular Membranes/physiology/ultrastructure
;
*Mitosis
;
Oligonucleotides, Antisense/pharmacology
;
Protein Structure, Tertiary
;
Rats
;
Recombinant Proteins/pharmacology
;
*Transcription Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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