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  • 1
    GFZ publications
    GFZ publications
    Konzeptentwicklungen zur Verarbeitung und Auswertung von MOMS-02 Daten : Endbericht zum Vorhaben FKZ 523-4001-1QS90103, MOMS BMBF-DARA (1995)
    Potsdam : Geoforschungszentrum
    Associated volumes
    Details Availability
    Call number: 21/STR 95/25
    In: Scientific technical report
    Type of Medium: GFZ publications
    Pages: 118 S.
    Series Statement: Scientific technical report / Geoforschungszentrum Potsdam 95,25
    Classification:
    Photogrammetry, Remote Sensing
    Location: Reading room
    Branch Library: GFZ Library
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  • 2
    GFZ publications
    GFZ publications
    Effectiveness of FUYO-1 (JERS)/OPS-SWIR bands for mineral exploration : final report (1995)
    Potsdam : Geoforschungszentrum
    Associated volumes
    Details Availability
    Call number: 21/STR 95/24
    In: Scientific technical report
    Type of Medium: GFZ publications
    Pages: 16, [20] Bl.
    Series Statement: Scientific technical report / Geoforschungszentrum Potsdam 95,24
    Classification:
    Photogrammetry, Remote Sensing
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  • 3
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    Phase transition kinetics for a Bose Einstein condensate in a periodically driven band system (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-05-12
    Description: The dynamical transition of an atomic Bose–Einstein condensate from a spatially periodic state to a staggered state with alternating sign in its wavefunction is experimentally studied using a one-dimensional phase modulated optical lattice. We observe the crossover from quantum to thermal fluctuations as the triggering mechanism for the nucleation of staggered states. In good quantitative agreement with numerical simulations based on the truncated Wigner method, we experimentally investigate how the nucleation time varies with the renormalized tunneling rate, the atomic density, and the driving frequency. The effective inverted energy band in the driven lattice is identified as the key ingredient which explains the emergence of gap solitons as observed in numerics and the possibility to nucleate staggered states from interband excitations as reported experimentally.
    Electronic ISSN: 1367-2630
    Topics: Physics
    Published by Institute of Physics (IOP)
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  • 4
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    Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients (2016)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2016-07-08
    Description: Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen ( PLG ) as a putative genetic risk factor for MS. Genotyping of PLG p.G420D (rs139071351) in 2160 MS patients, and 886 controls from Canada, identified 10 additional probands, two sporadic patients and one control with the variant. Segregation in families harboring the rs139071351 variant, identified p.G420D in 26 out of 30 family members diagnosed with MS, 14 unaffected parents, and 12 out of 30 family members not diagnosed with disease. Despite considerably reduced penetrance, linkage analysis supports cosegregation of PLG p.G420D and disease. Genotyping of PLG p.G420D in 14446 patients, and 8797 controls from Canada, France, Spain, Germany, Belgium, and Austria failed to identify significant association with disease ( P  = 0.117), despite an overall higher prevalence in patients (OR = 1.32; 95% CI = 0.93–1.87). To assess whether additional rare variants have an effect on MS risk, we sequenced PLG in 293 probands, and genotyped all rare variants in cases and controls. This analysis identified nine rare missense variants, and although three of them were exclusively observed in MS patients, segregation does not support pathogenicity. PLG is a plausible biological candidate for MS owing to its involvement in immune system response, blood-brain barrier permeability, and myelin degradation. Moreover, components of its activation cascade have been shown to present increased activity or expression in MS patients compared to controls; further studies are needed to clarify whether PLG is involved in MS susceptibility.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 5
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    Calcium-Iron Oxide as Energy Storage Medium in Rechargeable Oxide Batteries (2016)
    Wiley
    Details
    Publication Date: 2016-08-09
    Description: Rechargeable oxide batteries (ROB) comprise a regenerative solid oxide cell (rSOC) and a storage medium for oxygen ions. A sealed ROB avoids pumping loss, heat loss, and gas purity expenses in comparison with conventional rSOC. However, the iron oxide base storage medium degrades during charging–discharging cycles. In comparison, CaFe 3 O 5 has improved cyclability and a high reversible oxygen storage capacity of 22.3 mol%. In this study, we analyzed the redox mechanism of this compound. After a solid-state synthesis of CaFe 3 O 5 , we verified the phase composition and studied the redox reaction by means of X-ray diffraction, Mössbauer spectrometry, and scanning electron microscopy. Results show a great potential to operate the battery with this storage material during multiple charging–discharging cycles.
    Print ISSN: 0002-7820
    Electronic ISSN: 1551-2916
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Wiley
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  • 6
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    MET expression in melanoma correlates with a lymphangiogenic phenotype (2012)
    Oxford University Press
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    Publication Date: 2012-07-10
    Description: Melanomas contain high frequencies of tumorigenic cells and their tumorigenic capacity resides in several distinct subpopulations within melanoma. Since their metastatic potential is linked to their ability to recruit lymphatic vessels, we aimed at identifying lymphangiogenic subpopulations by comparative in vitro analysis of single cell clones derived from a melanoma of a single patient. Selected lymphangiogenic clones were then grafted into severe combined immunodeficient mice, where they induced lymphangiogenesis and metastasized into sentinel nodes, whereas non-lymphangiogenic clones from the same patient did not metastasize. Transcriptome analysis revealed high expression of vascular endothelial growth factor C (VEGF-C) and platelet derived growth factor C (PDGF-C) as well as of the met proto-oncogene (MET) and its targets to be associated with this lymphangiogenic phenotype. Screening of a set of independently isolated melanoma cell lines from other patients confirmed this association between expression of high levels of MET and of VEGF-C and PDGF-C. Hence, we provide a model to screen for the lymphangiogenic potential of tumor cells. We show that the lymphangiogenic potential is heterogeneously distributed among melanoma cells within one given tumor and is associated with activation of MET signaling.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 7
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    The Effects of Retrograde Reactions and of Diffusion on 40Ar-39Ar Ages of Micas (2011)
    Oxford University Press
    Details
    Publication Date: 2011-03-29
    Description: The effects of metamorphic reactions occurring during decompression were explored to understand their influence on the 40 Ar– 39 Ar ages of micas. Monometamorphic metasediments from the Lepontine Alps (Switzerland) reached lower amphibolite facies during the Barrovian metamorphism related to the collision between European and African (Adria) continental plates. Mineral assemblages typically composed of garnet, plagioclase, biotite, muscovite and paragonite (or margarite) were screened for petrological equilibrium, to focus on samples that record a minimum degree of retrogression. X-ray diffraction data indicate that some mineral separates prepared for 40 Ar– 39 Ar stepwise heating analysis are monomineralic, whereas others are composed of two white micas (muscovite with paragonite or margarite), or biotite and chlorite. In monomineralic samples 37 Ar/ 39 Ar and 38 Ar/ 39 Ar (proportional to Ca/K and Cl/K ratios) did not change and the resulting ages can be interpreted unambiguously. In mineral separates containing two white micas, Ca/K and Cl/K ratios were variable, reflecting non-simultaneous laboratory degassing of the two heterochemical Ar reservoirs. These ratios were used to identify each Ar reservoir and to unravel the age. In a chlorite–margarite–biotite calcschist equilibrated near 560°C and 0·65 GPa, biotite, margarite, and muscovite all yield ages around 18 Ma. At slightly higher grade (560–580°C, 0·8–0·9 GPa), the assemblage muscovite–paragonite–plagioclase is in equilibrium and remains stable during retrogression. In this case, muscovite and paragonite yield indistinguishable ages around 16·5 Ma. Above 590°C, paragonite was mostly consumed to form plagioclase 〉590°C, whereby the relict mica yields an age up to 5·6 Ma younger than muscovite. This partial or total resetting of the Ar clock in paragonite is interpreted to reflect plagioclase growth during decompression. Where biotite is present within this same assemblage, it systematically yields a younger age than muscovite, by 0·5–2 Ma. However, these biotites all show small amounts of retrograde chlorite formation. We conclude that even very minor chloritization of biotite is apparently a more effective process than temperature in resetting the Ar clock, as is the formation of plagioclase from paragonite decomposition. Multi-equilibrium thermobarometry is an excellent means to ensure that equilibrium in investigated samples is preserved, and this helps to obtain geologically meaningful metamorphic ages. However, even samples passing such equilibrium tests may still show retrograde effects that affect the Ar retention of micas. A more robust interpretation of such 40 Ar– 39 Ar results may require use of a second geochronometer, such as U–Pb on monazite.
    Print ISSN: 0022-3530
    Electronic ISSN: 1460-2415
    Topics: Geosciences
    Published by Oxford University Press
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  • 8
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    Eurasian ancestry in Africa [Genetics] (2014)
    National Academy of Sciences
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    Publication Date: 2014-02-19
    Description: The history of southern Africa involved interactions between indigenous hunter–gatherers and a range of populations that moved into the region. Here we use genome-wide genetic data to show that there are at least two admixture events in the history of Khoisan populations (southern African hunter–gatherers and pastoralists who speak non-Bantu...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Structure of the RNA polymerase domain of E. coli primase (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-31
    Description: All cellular organisms use specialized RNA polymerases called "primases" to synthesize RNA primers for the initiation of DNA replication. The high-resolution crystal structure of a primase, comprising the catalytic core of the Escherichia coli DnaG protein, was determined. The core structure contains an active-site architecture that is unrelated to other DNA or RNA polymerase palm folds, but is instead related to the "toprim" fold. On the basis of the structure, it is likely that DnaG binds nucleic acid in a groove clustered with invariant residues and that DnaG is positioned within the replisome to accept single-stranded DNA directly from the replicative helicase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keck, J L -- Roche, D D -- Lynch, A S -- Berger, J M -- New York, N.Y. -- Science. 2000 Mar 31;287(5462):2482-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall, no. 3206, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10741967" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Binding Sites ; Catalytic Domain ; Crystallography, X-Ray ; DNA Helicases/chemistry/metabolism ; DNA Primase/*chemistry/*metabolism ; DNA Replication ; DNA, Bacterial/metabolism ; DNA, Single-Stranded/*metabolism ; DNA-Directed RNA Polymerases/*chemistry/metabolism ; Escherichia coli/*enzymology/metabolism ; Metals/metabolism ; Models, Molecular ; Molecular Sequence Data ; Nucleic Acid Hybridization ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; RNA/biosynthesis ; Recombinant Proteins/chemistry/metabolism ; Templates, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases (2010)
    Nature Publishing Group (NPG)
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    Publication Date: 2010-05-21
    Description: Type II topoisomerases are required for the management of DNA tangles and supercoils, and are targets of clinical antibiotics and anti-cancer agents. These enzymes catalyse the ATP-dependent passage of one DNA duplex (the transport or T-segment) through a transient, double-stranded break in another (the gate or G-segment), navigating DNA through the protein using a set of dissociable internal interfaces, or 'gates'. For more than 20 years, it has been established that a pair of dimer-related tyrosines, together with divalent cations, catalyse G-segment cleavage. Recent efforts have proposed that strand scission relies on a 'two-metal mechanism', a ubiquitous biochemical strategy that supports vital cellular processes ranging from DNA synthesis to RNA self-splicing. Here we present the structure of the DNA-binding and cleavage core of Saccharomyces cerevisiae topoisomerase II covalently linked to DNA through its active-site tyrosine at 2.5A resolution, revealing for the first time the organization of a cleavage-competent type II topoisomerase configuration. Unexpectedly, metal-soaking experiments indicate that cleavage is catalysed by a novel variation of the classic two-metal approach. Comparative analyses extend this scheme to explain how distantly-related type IA topoisomerases cleave single-stranded DNA, unifying the cleavage mechanisms for these two essential enzyme families. The structure also highlights a hitherto undiscovered allosteric relay that actuates a molecular 'trapdoor' to prevent subunit dissociation during cleavage. This connection illustrates how an indispensable chromosome-disentangling machine auto-regulates DNA breakage to prevent the aberrant formation of mutagenic and cytotoxic genomic lesions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882514/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882514/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, Bryan H -- Burgin, Alex B -- Deweese, Joseph E -- Osheroff, Neil -- Berger, James M -- CA077373/CA/NCI NIH HHS/ -- GM033944/GM/NIGMS NIH HHS/ -- GM053960/GM/NIGMS NIH HHS/ -- GM08295/GM/NIGMS NIH HHS/ -- R01 CA077373/CA/NCI NIH HHS/ -- R01 CA077373-11S1/CA/NCI NIH HHS/ -- R01 CA077373-12/CA/NCI NIH HHS/ -- R01 GM033944/GM/NIGMS NIH HHS/ -- T32 CA009592/CA/NCI NIH HHS/ -- T32CA09592/CA/NCI NIH HHS/ -- England -- Nature. 2010 Jun 3;465(7298):641-4. doi: 10.1038/nature08974.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485342" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Base Sequence ; Catalytic Domain ; Crystallography, X-Ray ; DNA/*chemistry/genetics/*metabolism ; DNA Topoisomerases, Type I/*chemistry/*metabolism ; DNA Topoisomerases, Type II/*chemistry/*metabolism ; Kinetics ; Models, Molecular ; Molecular Sequence Data ; Saccharomyces cerevisiae/*enzymology ; Tyrosine
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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