Publication Date:
2004-01-17
Description:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Park, Jy-Young -- Su, You-Qiang -- Ariga, Miyako -- Law, Evelyn -- Jin, S-L Catherine -- Conti, Marco -- HD20788/HD/NICHD NIH HHS/ -- HD31398/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 30;303(5658):682-4. Epub 2004 Jan 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Reproductive Biology and Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14726596" target="_blank"〉PubMed〈/a〉
Keywords:
Amphiregulin
;
Animals
;
Betacellulin
;
Chorionic Gonadotropin/pharmacology
;
EGF Family of Proteins
;
Epidermal Growth Factor/genetics/*metabolism
;
Epiregulin
;
Female
;
Gene Expression Regulation
;
Glycoproteins/genetics/*metabolism
;
Granulosa Cells/metabolism
;
Intercellular Signaling Peptides and Proteins/genetics/*metabolism
;
Luteinizing Hormone/pharmacology/*physiology
;
Meiosis
;
Mice
;
Mice, Inbred C57BL
;
Oocytes/physiology
;
Organ Culture Techniques
;
Ovarian Follicle/*physiology
;
Ovulation/*physiology
;
Paracrine Communication
;
RNA, Messenger/genetics/metabolism
;
Receptor, Epidermal Growth Factor/metabolism
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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