Publication Date:
1994-05-13
Description:
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grabstein, K H -- Eisenman, J -- Shanebeck, K -- Rauch, C -- Srinivasan, S -- Fung, V -- Beers, C -- Richardson, J -- Schoenborn, M A -- Ahdieh, M -- New York, N.Y. -- Science. 1994 May 13;264(5161):965-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunex Research and Development Corporation, Seattle, WA 98101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8178155" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Cells, Cultured
;
*Cloning, Molecular
;
Haplorhini
;
Humans
;
Interleukin-15
;
Interleukin-2/immunology/metabolism/pharmacology
;
Interleukins/chemistry/*genetics/metabolism/pharmacology
;
Killer Cells, Lymphokine-Activated/immunology
;
Leukocytes, Mononuclear/immunology/metabolism
;
Lymphocyte Activation
;
Lymphocyte Culture Test, Mixed
;
Molecular Sequence Data
;
Protein Structure, Secondary
;
Receptors, Interleukin-2/immunology/*metabolism
;
T-Lymphocytes/*immunology
;
T-Lymphocytes, Cytotoxic/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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