ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Novel Bifunctional Bridging Functions for A1-B29 Crosslinking of the Two Insulin ChainsThe positions A1 and B29 of the insulin molecule are crosslinked by the new bifunctional groups U and V. These insulin derivatives are convertible by oxydative sulfitolysis into A1-B29 crosslinked hexa-S-sulfonates, which recombine by tributylphosphan/O2 in high yields to the A1-B29 insulin derivatives, correctly reconstructing the disulfide system, and from which the bridging function is smoothly removable by acidolysis. The example of the bridging function U demonstrates that this principle is also suitable for the combination of both isolated single chains.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19823240619
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