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Electronic Resource

First results from cryogenic target implosions on OMEGA : Review,Tutorial and Invited Papers from the 43rd Annual Meeting of the APS Division of Plasma Physics (2002)

Stoeckl, C. ; Chiritescu, C. ; Delettrez, J. A. ; [et al.]

[S.l.] : American Institute of Physics (AIP)

Physics of Plasmas 9 (2002), S. 2195-2201

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ISSN: 1089-7674

Source: AIP Digital Archive

Topics: Physics

Notes: Initial results from direct-drive spherical cryogenic target implosions on the 60-beam OMEGA laser system [T. R. Boehly, D. L. Brown, R. S. Craxton et al., Opt. Commun. 133, 495 (1997)] are presented. These experiments are part of the scientific base leading to direct-drive ignition implosions planned for the National Ignition Facility (NIF) [W. J. Hogan, E. I. Moses, B. E. Warner et al., Nucl. Fusion 41, 567 (2001)]. Polymer shells (1-mm diam with walls 〈3 μm) are filled with up to 1000 atm of D2 to provide 100-μm-thick ice layers. The ice layers are smoothed by IR heating with 3.16-μm laser light and are characterized using shadowgraphy. The targets are imploded by a 1-ns square pulse with up to ∼24 kJ of 351-nm laser light at a beam-to-beam rms energy balance of 〈3% and full-beam smoothing. Results shown include neutron yield, secondary neutron and proton yields, the time of peak neutron emission, and both time-integrated and time-resolved x-ray images of the imploding core. The experimental values are compared with 1-D numerical simulations. The target with an ice-layer nonuniformity of σrms=9 μm showed 30% of the 1-D predicted neutron yield. These initial results are encouraging for future cryogenic implosions on OMEGA and the NIF. © 2002 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.1458586

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2

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Profit Sharing in the Office: A Group Incentive Plan (1935)

Lund, L. H.

Saranac Lake, N.Y., etc. : Periodicals Archive Online (PAO)

Management Review. 24:10 (1935:Oct.) 294

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ISSN: 0025-1895

Topics: Economics

URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:7504-1935-024-10-000002

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3

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The role of iron in the cytotoxicity of crocidolite

Chao, C. ; Shea, R. ; Lund, L. ; [et al.]

Amsterdam : Elsevier

Free Radical Biology and Medicine 15 (1993), S. 520

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ISSN: 0891-5849

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(93)90371-Z

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4

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Plasminogen activator inhibitor-type 1 in Lewis lung carcinoma (1990)

Kristensen, P. ; Pyke, C. ; Lund, L. R. ; [et al.]

Springer

Histochemistry and cell biology 93 (1990), S. 559-566

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ISSN: 1432-119X

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Plasminogen activator inhibitor-type 1 (PAI-1) was identified in extracts of Lewis lung carcinoma, and its immunohistochemical localization was studied together with that of urokinase-type (u-PA) and tissue-type (t-PA) plasminogen activators. All primary tumors (n=11) contained heterogeneously distributed immunoreactivity against each of the three components. Most often, areas that contained u-PA immunoreactivity also contained PAI-1 immunoreactivity. However, several areas showed a strong u-PA immunoreactivity, but no or low PAI-1 immunoreactivity. The latter staining pattern was only found in periferal areas, and usually in areas with histological signs of tissue destruction. Lung metastases always contained u-PA immunoreactivity, while PAI-1 immunoreactivity was found in most, but not all, metastases. t-PA immunoreactivity was found in a few scattered tumor cells, in primary carcinomas as well as metastases. Controls that included absorption with highly purified antigen preparations and immunoblotting, indicated that all the immunoreactivity represented genuine PAI-1, u-PA and t-PA, respectively. The results are consistent with an assumption that the plasminogen activation system, and particularly u-PA and PAI-1, plays a role in regulation of breakdown of extracellular matrix proteins during invasive growth in this carcinoma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00272198

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5

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Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy (1976)

Eichelbaum, M. ; Bertilsson, L. ; Lund, L. ; [et al.]

Springer

European journal of clinical pharmacology 9 (1976), S. 417-421

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ISSN: 1432-1041

Keywords: Plasma levels ; carbamazepine ; carbamazepine-10 ; 11-epoxide ; chronic treatment ; psychomotor epilepsy

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Carbamazepine and its epoxide in plasma were measured by liquid chromatography in 25 patients treated with a mean dose of carbamazepine of 12.5±3.3 mg/kg body weight. The mean concentrations of parent drug and metabolite were 5.4±2.5 µg/ml and 1.10±0.42 µg/ml, respectively. A significant correlation was found between the plasma concentrations of the two compounds (r=0.64; p〈0.001), but marked interindividual variation existed in the ratio of carbamazepine to epoxide. Based on simultaneous measurements in plasma and cerebrospinal fluid, the unbound fraction of carbamazepine in plasma was of the order of 20% as compared to 45% for the epoxide. Thirteen ambulant patients suffering from partial epilepsy with complex symptomatology, who were already being treated with phenytoin in optimal doses (plasma level 14–20 µg/ml) were also given carbamazepine. At plasma levels of the latter of about 5 µg/ml there was no further reduction in the frequency of partial or generalized epileptic seizures. In five patients the dose was increased to produce plasma concentrations of 7 – 8 µg/ml. There was still no improvement and side-effects were seen in three patients.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00606558

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6

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Pharmacokinetics of single and multiple doses of phenytoin in man (1974)

Lund, L. ; Alvan, G. ; Berlin, A. ; [et al.]

Springer

European journal of clinical pharmacology 7 (1974), S. 81-86

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ISSN: 1432-1041

Keywords: Phenytoin ; single- and multiple dose pharmacokinetics ; dose-dependent kinetics ; bioavailability ; plasma concentration ; man

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Plasma concentration of phenytoin (diphenylhydantoin, DPH) have been studied in 5 volunteers after single oral and iv doses (5.0 mg sodium DPH/kg), and after multiple oral doses (2.0 mg sodium DPH/kg b.i.d. for 12 days). The data were analysed according to a one compartment model. The plasma half-life was 14.5 h±1.2 S.D. after i.v. administration, its apparent volume of distribution varied little (0.52 l/kg±0.04) and its bioavailability ranged between 0.70 and 1.0 (mean 0.87). After oral administration peak plasma concentrations were reached in 4 to 12 h. Elimination curves were slightly convex, probably due to an effect of slow absorption. Steady-state plasma levels varied twofold between individuals after multiple oral doses and exceeded those predicted from the single i.v. dose by 29 to 77%. The discrepancy was considered to be due to transition to dose-dependent kinetics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00561319

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7

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Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin (1974)

Lund, L.

Springer

European journal of clinical pharmacology 7 (1974), S. 119-124

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ISSN: 1432-1041

Keywords: Anticonvulsants ; phenytoin ; diphenylhydantoin ; bioavailability ; generic inequivalence ; pharmacokinetics

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The plasma levels of phenytoin (diphenylhydantoin, DPH) in epileptic patients were significantly higher after treatment with either of two preparations containing the sodium salt of DPH, than after treatment with the same dose of the free acid. This was confirmed in both short and long term studies, and in the latter increased plasma levels of DPH were accompanied by better control of generalized seizures. The degree of acute side-effects in 6 out of 10 patients whose treatment was changed from DPH-acid to DPH-sodium was proportional to the plasma level of DPH; the latter varied from 22.8 to 34.9 µg/ml in affected patients. After a single oral dose in healthy volunteers, the sodium salt of DPH showed much better bioavailability than the free acid. The differences in bioavailability in patients and volunteers probably depended on differences in particle size in the preparations of the sodium salt of DPH and its free acid. The excipient, lactose or starch, did not seem to affect the bioavailability of the two formulations of sodium-DPH.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00561325

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8

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The practice of leaching boron and soluble salts from fly ash-amended soils (1979)

Phung, H. T. ; Lam, H. V. ; Page, A. L. ; [et al.]

Springer

Water, air & soil pollution 12 (1979), S. 247-254

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ISSN: 1573-2932

Source: Springer Online Journal Archives 1860-2000

Topics: Energy, Environment Protection, Nuclear Power Engineering

Notes: Abstract The leachability of B and salts from two fly ash-amended soils was conducted in a column leaching experiment. Fly ash was applied to the surface 3 cm of a Baywood (acid) sand and an Arizo (calcareous) sandy, loam at 5% by weight; the columns were continously leached with Colorado River water at two different pH's. Boron from fly ash was solubilized more readily in the Baywood than in the Arizo soil. Addition of fly ash increased B levels in the leachates from 0.25 to 2.35 μg ml−1 (Baywood) and 0.93 μg ml−1 (Arizo). Acidified leaching water had no significant effect on B leaching patterns but resulted in leaching higher soluble salts. Approximately 348 and 161 cm of water for the Arizo and the Baywood soils respectively, would be required to reduce the B concentration below a critical limit for B sensitive crops. It is suggested that crops planted when fly ash is applied for disposal/recycling on land should be both salt and B tolerant.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01047127

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