Publication Date:
2014-07-16
Description:
Article The role of metabolic reprogramming in the regulation of innate inflammatory response remains incompletely understood. Here, the authors show that pyruvate kinase M2-mediated aerobic glycolysis contributes to inflammatory response, and that inhibition of this pathway protects mice from lethal endotoxemia and sepsis. Nature Communications doi: 10.1038/ncomms5436 Authors: Liangchun Yang, Min Xie, Minghua Yang, Yan Yu, Shan Zhu, Wen Hou, Rui Kang, Michael T. Lotze, Timothy R. Billiar, Haichao Wang, Lizhi Cao, Daolin Tang
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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