ISSN:
1573-1561
Keywords:
Smaller tea tortrix
;
Adoxophyes fasciata
;
(Z)-9-tetradecenyl acetate
;
(Z)-11-tetradecenyl acetate
;
(E)-11-tetradecenyl acetate
;
10-methyl-dodecyl acetate
;
hexamethylphosphoric triamide
;
1,3-dimethyl-2-oxo-hex-ahydropyrimidine
;
1,3-dimethyl-2-imidazolidinone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Hexamethylphosphoric triamide (HMPA) is a good solvent for the alkylation of terminal acetylenes; however, it has been proven to be a carcinogen towards rats and should be considered as a serious risk to man when a large-scale synthesis is involved. Thus the search for a safe alternative is important. The physical properties of 1,3-dimethyl-2-imidazolidinone (DMI) are similar to DMPU (1,3-dimethyl-2-oxo-hexahydropyrimidine) and HMPA, but the potential toxicological risk of DMI is less than DMPU and HMPA. When used in the alkylation of terminal acetylenes, DMI is comparable with HMPA, thus it is a good alternative solvent to the carcinogen HMPA in the alkylation because it provides a safer working environment than DMPU and HMPA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00982095
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