Publication Date:
2011-12-09
Description:
Three new sesquiterpenes, schisansphenins A ( 1 ) and B ( 2 ) and (−)- γ -cuparenol ( 3 ), were isolated from an acetone extract of the fruits of Schisandra sphenanthera. The known compound 4 was isolated for the frist time from a natural source. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D-NMR experiments ( 1 H, 1 H-COSY, HMQC, HMBC, and NOESY). A plausible biogenetic pathway for schisansphenin B ( 2 ) is proposed. Compounds 2 and 3 significantly reduced activation of NF-AT and NF- κ B in the luciferase-reporter assay.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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