ISSN:
1432-1432
Keywords:
Ni(II)
;
Nucleotides
;
Nucleosides
;
Purine Purine bases
;
Chemical evolution
;
Binary complexes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The interactions of Ni(II) cation with a representative suite of purine bases and the respective nucleosides and nucleotides have been studied by ultraviolet difference spectroscopy. Apparent association constants, Kapp, were determined for each system at pH 7.0, using computer linear regression coupled with an iteration technique. The specificity of binding of Ni2+ for the purine nucleotides studied at pH 7.0 was 5′-GMP 〉 5′-IMP 〉 5′-AMP; a similiar ordering was also found for the respective nucleosides and bases. In this study binding was not observed for the suite of pyramidines used, although a Ni2+ - cytidine complex has been observed (Fiskin and Beer, 1965). It was also found that Ni2+ bound more strongly to the purine 5′-nucleotides than to the respective nucleosides and bases. These trends are explained in terms of metal-ligand bonds and available bonding positions on the ligands. A role for metal-ion-nucleotide types of complexes is suggested in the processes that might have given rise to the origin of life.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01810833
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