Publication Date:
2018-03-14
Description:
Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression, Published online: 13 March 2018; doi:10.1038/s41467-018-03327-4 Eya proteins are characterised by phosphatase activity associated with both the evolutionary conserved region and the less conserved N-terminal domain (NTD). Here the authors show that NTD mediates the interaction with PP2A and regulates c-Myc phosphorylation and stability, potentially switching PP2A from a tumour suppressor to an oncogene.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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