Publication Date:
2015-11-07
Description:
An efficient one-pot synthesis of pyrazolo[3,4- d ]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, NMR ( 1 H and 13 C) spectroscopy and HRMS (ESI) spectrometry. The crystal structure of 4-ethoxy-6-(2-nitrophenyl)-1-phenyl-1 H -pyrazolo[3,4- d ]pyrimidine was determined by single crystal X-ray diffraction. Beilstein J. Org. Chem. 2015, 11, 2125–2131. doi:10.3762/bjoc.11.229
Keywords:
four-componentone-potpyrazolo[3,4-d]pyrimidinesodium alkoxide
Electronic ISSN:
1860-5397
Topics:
Chemistry and Pharmacology
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