ISSN:
1573-8256
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Technology
Notes:
Conclusions 1. It is shown that conventional methods of administration of drugs provide high concentration of preparation in a small volume of subcutaneous fat with a further slow diffusion into the microcapillary bed. If the method of injection with a syringe is used, the site of injection is injured by the needle and an increase in the hydrostatic pressure is caused by an artificial edema. 2. The TCADS method developed in our laboratory is a noninvasive method of local administration of drugs into biological tissues without injury to skin. It is based on increasing skin permeability by sequential stimulation and inhibition of perspiration in the contrasting heating-cooling cycle. Administration of preparation by the TCADS method forms a three-dimensional net-shaped structure of drug distribution in subcutaneous fat. Lymph and blood capillaries are surrounded with molecules of preparation, which provides a high rate of absorption of preparation from subcutaneous fat into the lymph capillary bed. 3. Exposure to contrasting temperatures during the TCADS procedure is shown to be an efficient method of stimulation of lymphopoiesis. The morphological and cytological structure of regional lymphonodi is modified by TCADS so that the immune function and morphological support of self-clearance reaction are activated. 4. The TCADS method is shown to be an efficient method of noninvasive administration of drugs at prelymphatic level without injury to skin. It is recommended to use TCADS as a clinical method of intensification of rheological and diffusion processes in the zone of impregnation with drug.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02369090
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