ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The purpose of the present study was to develop a polymer film loaded with drug toeffectively prevent pin tract infection. It was found that the polymer, poly ethylene-co-vinyl acetateblended with tetrahydrofuran, showed better flexibility and deformability than the other polymers:poly caprolactone18 and poly caprolactone44. Polymer films, poly ethylene-co-vinyl acetate, weredivided into five testing groups dependent on the loading concentration of rifampici (5, 10, 15, and20 wt %). The surface morphology of polymer films was examined by a scanning electronmicroscopy. It was found that the concentration of drug was a main factor to determine theroughness of the film. Considering the roughness of polymer films, 5 wt % of rifampicin might bethe maximum concentration for further applications. Hence, the antibiotic drug-loaded polymerfilms were manufactured by mixing poly(ethylene-co-vinylacetate) and tetrahydrofuran withrifampicin(antibiotic drug). The film cast was designed as a shape of disk (inner Ø5mm and outerØ20mm) to be suitable for pins for external fixation in orhtopaedics. The drug-loaded polymersolvent, the amount of 0.6cc, was molded into the disk-shaped film and dried into a airtight box at15℃ for 24 hrs. The drug release characteristics(1, 2, 3, 4 and 5 wt%) were examined as a functionof soaking time in phosphate buffered saline (PBS, 10 ml) using an enzyme-linked immunosorbentassay. Rifampicin was linearly released for first 100 hrs(~4 days) for all antibiotic drug-loadedpolymer films. Afterward, the drug was released at a slower pace as a function of square root oftime until 1000 hrs (~40 days). This slow drug release can be explained by their hydrophobiccharacteristics of poly ethylene-co-vinyl acetate and rifampicin. The antibiotic drug-loaded polymerfilm can be intrinsically able to prevent the bacteria adhesion by wrapping the pin track area, andperform active and effective infection-resistant by a sustained antibiotic-release
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.533.pdf
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