ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
A near-field scanning microwave microscope (NSMM) is used to study the physicalproperties of DNA strands with a specific sequence and image lamda-DNA bundles. After thehybridization process between target and capture sequences, specific DNA binding events leads tomicrowave reflection coefficient (S11) changes of the NSMM. These changes are caused by amodification of the physical dielectric constant due to sequence specific DNA binding. This studydemonstrates significant potential of the NSMM as a nondestructive and noncontact tool to detectDNA strands without a target-probe amplification process and as a valuable technique to understandthe physical property of DNA
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.321-323.1040.pdf
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