Publication Date:
2013-08-29
Description:
An experiment was flown on Spacelab to confirm the results of the Cytos 2 experiment on Salyut 7, which found an increase in minimal inhibitory concentration in in-flight cultures, i.e., an increase of antibiotic resistance. The 1 g centrifuge on Biorack was also used to differentiate the effects of cosmic rays and microgravity. The antibiotic sensitivity of bacteria cultivated in vitro during orbital flight was studied. The bacteria was E. coli, the antibiotic was Colistin. An increase of antibiotic resistance is observed. Three explanations are offered: stimulation of bacterial proliferation in space; a relationship between the transport of antibiotics into cells and modifications of cellular envelope permeability; and a combined effect of both phenomena.
Keywords:
MATERIALS PROCESSING
Type:
ESA, Biorack on Spacelab D1: An Overview of the First Flight of Biorack, an ESA Facility for Life Sciences Research in Microgravity; p 45-51
Format:
text
Permalink