ISSN:
0899-0042
Keywords:
stereochemistry
;
quinacrine
;
enantiomers
;
enantioselectivity
;
circular dichroism
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Absolute configurations have been assigned to the enantiomers of the antimalarial drug quinacrine dihydrochloride. Condensation of (-)-(R)-4-amino-1-diethylaminopentane (from L-glutamic acid) with 6,9-dichloro-2-methoxyacridine gave (-)-(R)-6-chloro-9-(4′-diethylamino-1′-methylbutyl) amino-2-methoxyacridine [(-)-(R)-quinacrine] while (+)-(S)-quinacrine was obtained from the enantiomeric diamine.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530030510
Permalink