Publication Date:
2002-03-16
Description:
An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kew, Olen -- Morris-Glasgow, Victoria -- Landaverde, Mauricio -- Burns, Cara -- Shaw, Jing -- Garib, Zacarias -- Andre, Jean -- Blackman, Elizabeth -- Freeman, C Jason -- Jorba, Jaume -- Sutter, Roland -- Tambini, Gina -- Venczel, Linda -- Pedreira, Cristina -- Laender, Fernando -- Shimizu, Hiroyuki -- Yoneyama, Tetsuo -- Miyamura, Tatsuo -- van Der Avoort, Harrie -- Oberste, M Steven -- Kilpatrick, David -- Cochi, Stephen -- Pallansch, Mark -- de Quadros, Ciro -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):356-9. Epub 2002 Mar 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA. okew@cdc.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896235" target="_blank"〉PubMed〈/a〉
Keywords:
5' Untranslated Regions
;
Adolescent
;
Animals
;
Capsid/genetics
;
Capsid Proteins
;
Child
;
Child, Preschool
;
*Disease Outbreaks
;
Dominican Republic/epidemiology
;
Female
;
Genes, Viral
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Haiti/epidemiology
;
Humans
;
Immunization Programs
;
Infant
;
Male
;
Mice
;
Molecular Sequence Data
;
Point Mutation
;
Poliomyelitis/*epidemiology/prevention & control/transmission/*virology
;
Poliovirus/classification/*genetics/isolation & purification/*pathogenicity
;
Poliovirus Vaccine, Oral/*adverse effects
;
Population Surveillance
;
Recombination, Genetic
;
Vaccination
;
Virulence
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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