Publication Date:
2013-09-14
Description:
Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of research comes in part from the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that uncovered naturally arising, broad and potent HIV-1-neutralizing antibodies (bNAbs). These antibodies can protect against infection and suppress established HIV-1 infection in animal models. The finding that these antibodies develop in a fraction of infected individuals supports the idea that new approaches to vaccination might be developed by adapting the natural immune strategies or by structure-based immunogen design. Moreover, the success of passive immunotherapy in small-animal models suggests that bNAbs may become a valuable addition to the armamentarium of drugs that work against HIV-1.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970325/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970325/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, Florian -- Mouquet, Hugo -- Dosenovic, Pia -- Scheid, Johannes F -- Scharf, Louise -- Nussenzweig, Michel C -- AI 100148-01/AI/NIAID NIH HHS/ -- AI 100663-01/AI/NIAID NIH HHS/ -- P01 AI081677/AI/NIAID NIH HHS/ -- P01 AI100148/AI/NIAID NIH HHS/ -- UM1AI100663/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Sep 13;341(6151):1199-204. doi: 10.1126/science.1241144.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. fklein@rockefeller.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24031012" target="_blank"〉PubMed〈/a〉
Keywords:
AIDS Vaccines/*therapeutic use
;
Acquired Immunodeficiency Syndrome/prevention & control/*therapy
;
Antibodies, Neutralizing/biosynthesis/genetics/*immunology
;
HIV Antibodies/biosynthesis/genetics/*immunology
;
HIV Infections/*therapy
;
HIV-1/*immunology
;
Humans
;
Immunotherapy
;
Viral Envelope Proteins/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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