Publication Date:
2011-11-26
Description:
Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout the brain. We investigated this brain-state shift in humans. During exposure to a fear-related acute stressor, responsiveness and interconnectivity within a network including cortical (frontoinsular, dorsal anterior cingulate, inferotemporal, and temporoparietal) and subcortical (amygdala, thalamus, hypothalamus, and midbrain) regions increased as a function of stress response magnitudes. beta-adrenergic receptor blockade, but not cortisol synthesis inhibition, diminished this increase. Thus, our findings reveal that noradrenergic activation during acute stress results in prolonged coupling within a distributed network that integrates information exchange between regions involved in autonomic-neuroendocrine control and vigilant attentional reorienting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hermans, Erno J -- van Marle, Hein J F -- Ossewaarde, Lindsey -- Henckens, Marloes J A G -- Qin, Shaozheng -- van Kesteren, Marlieke T R -- Schoots, Vincent C -- Cousijn, Helena -- Rijpkema, Mark -- Oostenveld, Robert -- Fernandez, Guillen -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1151-3. doi: 10.1126/science.1209603.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. erno.hermans@donders.ru.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22116887" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
Adrenergic Neurons/physiology
;
Adrenergic beta-Antagonists/pharmacology
;
Adult
;
Affect
;
Attention
;
Autonomic Nervous System/physiology
;
Brain/*physiology
;
Brain Mapping
;
Female
;
Functional Neuroimaging
;
Heart Rate
;
Humans
;
Hydrocortisone/analysis
;
Locus Coeruleus/physiology
;
Magnetic Resonance Imaging
;
Male
;
Metyrapone/pharmacology
;
Nerve Net/*physiology
;
Neurosecretory Systems/physiology
;
Neurotransmitter Agents/*physiology
;
Norepinephrine/*physiology
;
Receptors, Adrenergic, beta/physiology
;
Saliva/chemistry
;
Stress, Psychological/*physiopathology/psychology
;
Young Adult
;
alpha-Amylases/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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