Publication Date:
2000-09-29
Description:
In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balsalobre, A -- Brown, S A -- Marcacci, L -- Tronche, F -- Kellendonk, C -- Reichardt, H M -- Schutz, G -- Schibler, U -- New York, N.Y. -- Science. 2000 Sep 29;289(5488):2344-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departement de Biologie Moleculaire, Sciences II, Universite de Geneve, 30 Quai Ernest Ansermet, CH-1211 Geneve, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11009419" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Biological Clocks/*physiology
;
Cell Cycle Proteins
;
Cell Line
;
Circadian Rhythm/*physiology
;
*DNA-Binding Proteins
;
Dexamethasone/analogs & derivatives/*pharmacology
;
Female
;
*Gene Expression Regulation/drug effects
;
Kidney/metabolism
;
Liver/metabolism
;
Male
;
Mice
;
Mice, Inbred Strains
;
Mutation
;
Myocardium/metabolism
;
Neurons/metabolism
;
Nuclear Proteins/genetics/metabolism
;
Period Circadian Proteins
;
Rats
;
Receptors, Glucocorticoid/genetics/metabolism
;
*Signal Transduction
;
Suprachiasmatic Nucleus/metabolism
;
Transcription Factors/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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