Publication Date:
1985-01-25
Description:
Haloperidol, a widely used antipsychotic drug, was tested for its ability to block the behavioral response to amphetamine and to elicit catalepsy in rats treated with saline or ascorbic acid (1000 milligrams per kilogram of body weight). By itself, ascorbic acid failed to exert significant behavioral effects, but it enhanced the antiamphetamine and cataleptogenic effects of haloperidol (0.1 or 0.5 milligrams per kilogram). These results, combined with a growing body of biochemical evidence, suggest that ascorbic acid plays an important role in modulating the behavioral effects of haloperidol and related antipsychotic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rebec, G V -- Centore, J M -- White, L K -- Alloway, K D -- DA 02451/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1985 Jan 25;227(4685):438-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4038426" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Ascorbic Acid/*pharmacology
;
Behavior, Animal/*drug effects
;
Catalepsy/chemically induced
;
Dextroamphetamine/pharmacology
;
Drug Synergism
;
Haloperidol/*pharmacology
;
Humans
;
Male
;
Motor Activity/drug effects
;
Rats
;
Rats, Inbred Strains
;
Receptors, Dopamine/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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