Publication Date:
1981-09-25
Description:
A large, transient reduction in the population size of human fibroblasts in early passages significantly increases the variability of the life-spans of cultures in comparison to control cultures, as predicted by the commitment theory of cellular aging. The theory also predicts that a constant population of noncycling cells will appear in the later part of the culture life-span. This was confirmed by labeling the cells in culture with tritiated thymidine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holliday, R -- Huschtscha, L I -- Kirkwood, T B -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280670" target="_blank"〉PubMed〈/a〉
Keywords:
*Cell Division
;
*Cell Survival
;
Cells, Cultured
;
Fibroblasts/*physiology
;
Humans
;
Lung/cytology
;
Probability
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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