Publication Date:
1990-11-23
Description:
Sjogren's syndrome is an autoimmune disease that is characterized by dryness of the mouth and eyes. The loss of salivary and lacrimal gland function is accompanied by lymphocytic infiltration. Because similar symptoms and glandular pathology are observed in certain persons infected with human immunodeficiency virus (HIV), a search was initiated for a possible retroviral etiology in this syndrome. A human intracisternal A-type retroviral particle that is antigenically related to HIV was detected in lymphoblastoid cells exposed to homogenates of salivary tissue from patients with Sjogren's syndrome. Comparison of this retroviral particle to HIV indicates that they are distinguishable by several ultrastructural, physical, and enzymatic criteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garry, R F -- Fermin, C D -- Hart, D J -- Alexander, S S -- Donehower, L A -- Luo-Zhang, H -- AI 22720/AI/NIAID NIH HHS/ -- AI 28048/AI/NIAID NIH HHS/ -- DC 00712/DC/NIDCD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1990 Nov 23;250(4984):1127-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1701273" target="_blank"〉PubMed〈/a〉
Keywords:
Centrifugation, Density Gradient
;
*HIV/immunology/ultrastructure
;
HIV Antigens/analysis
;
Humans
;
Magnesium/pharmacology
;
Manganese/pharmacology
;
Microscopy, Electron
;
RNA-Directed DNA Polymerase/metabolism
;
*Retroviridae/immunology/ultrastructure
;
Salivary Glands/microbiology
;
Sjogren's Syndrome/*microbiology
;
Virion/enzymology/*isolation & purification/ultrastructure
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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