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  • 1
    Electronic Resource
    Electronic Resource
    Heavy ion-induced DNA double-strand breaks with yeast as a model system (1995)
    Springer
    Radiation and environmental biophysics 34 (1995), S. 95-99 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Cells of diploid yeast,Saccharomyces cerevisiae, were exposed to a variety of energetic heavy ions (provided by the UNILAC facility at the Gesellschaft für Schwerionenforschung, GSI),241Amα-particles and 80-keV x-rays after which they were assessed for DNA double-strand breaks (DSB) using either the neutral sedimentation or the pulsed-field gel electrophoresis (PFGE) technique. Both yielded comparable results. The DSB production cross-sections are compared with inactivation studies performed for the same cells under identical conditions. The measurements show that with lighter ions DSB induction cross-sections increase with linear energy transfer (LET), but the situation is less clear with the heavier ions. A close parallelism was found between DSB induction and cell inactivation in these yeast cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01275213
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Induction and repair of DNA double-strand breaks in human fibroblasts after particle irradiation (1998)
    Elsevier
    Details
    Publication Date: 1998-01-01
    Print ISSN: 0273-1177
    Electronic ISSN: 1879-1948
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Published by Elsevier
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    PAPER CURRENT
  • 3
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    Heavy ion induced DNA-DSB in yeast and mammalian cells (1994)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: Molecular changes at the DNA are assumed to be the main cause for radiation effects in a number of organisms. During the course of the last decades techniques have been developed for measuring DNA double-strand breaks (dsb), generally assumed to be the most critical DNA lesions. The outcome of all those different approaches portrays a collection of data useful for a theoretical description of radiation action mechanisms. However, in the case of heavy ion induced DNA dsb the picture is not quite clear yet and further projects and strategies have to be developed. The biological systems studied in our group are yeast and mammalian cells. While in the case of yeast cells technical and methodical reasons highlight these organisms mammalian cells reach greater importance when dsb repair studies are performed. In both types of organisms the technique of pulsed-field gel electrophoresis (PFGE) is applied, although with different modifications and evaluation procedures mainly due to the different genome sizes.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA. Ames Research Center, Minutes of the 12th Joint NASA(DARA-DLR Life Sciences Program Working Group Meeting; p 15-17
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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