ISSN:
1573-3297
Keywords:
period gene
;
rhythms
;
circadian
;
lovesong
;
DNA
;
RNA
;
per protein
;
thronine-glycine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Psychology
Notes:
Abstract The period (per) gene inDrosophila has made a major contribution to the emerging field of molecular ethology. Mutations at this locus alter a number of temporally programmed phenotypes, such as the 24-h circadian locomotor activity cycle and the 60-s male love-song cycle. Molecular analysis ofper has revealed that it encodes a conceptual protein of approximately 1200 amino acids. A striking feature of theper protein is a series of alternating threonine-glycine residues, which, when removed byin vitro mutagenesis, alter song periodicity but not circadian periodicity. Evolutionary implications of this, and of species differences amongper genes, are discussed. The threonine-glycine region is similar to a serine-glycine repeat found in mammalian proteoglycans. Based on this observation and other experiments, a model has been proposed, which suggests that theper protein may determine periodicity by modulating intercellular communication. Theper protein is localized in the eye, brain, and other nonneural tissues, and immunochemical staining appears to cycle in intensity in the visual system and some brain cells. Perhaps some of theseper + staining cells represent the anatomical concomitant of “the clock”.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01067790
Permalink
