ISSN:
1573-8221
Keywords:
8, 16-diazasteroid
;
diclofenac sodium
;
prednisolone
;
antiinflammatory activity
;
hormonal effects
;
structure-activity correlation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Antiinflammatory activity and mechanism of action are studied for seven compounds of the 8,16-diazasteroid series. It is established that the antiinflammatory activity of the compounds is increased on the whole due to the reduced ketofunction in the 12 position of 8,16-diazasteroid as well as for the introduction of methoxy groups in the 2 and 3 position or phenol substitute in the 16 position. The activity of compounds VI and VII also depends on the inflammation model or on the pain reaction and differs significantly from the effectiveness of diclofenac sodium and prednisolone. Unlike the latter, the compounds under study are virtually devoid of hormonal activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445865
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