ISSN:
1573-8221
Keywords:
psychostimulators
;
bromantane
;
dopamine
;
striatum
;
microdialysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract It is demonstrated that bromantane induces a pronounced and prolonged (8 h) increase in the release of dopanime. Tetrodotoxin (10−6 M) perfused via a microdialysis probe partially inhibits the bromantane-induced release of dopamine. The extracellular content of the dopamine metabolites 3,4-dioxyphenylacetic and homovanillic acids is slightly decreased. The possible mechanisms of action of bromantane on the dopamin- and serotoninergic systems of the brain are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445840
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