ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The synthesis of substituted 3,4,5,6-tetrahydro-12-aza-β-carbolines on the basis of the corresponding 7-azatryptamines was realized using the Bischler-Napieralski and Pictet-Spengler reactions. The effect of the character of the acylating residue in the synthesis of 12-aza-β-carboline derivatives via the Bischler-Napieralski reaction was studied. It was established that if the N-acylating group is a phenylacetic-acid residue, oxidation by air oxygen occurs along with cyclodehydration, and the corresponding ketone, 3-benzoyl-5,6-dihydro-12-aza-β-carboline, is formed instead of the normal product, the 3-benzyl-5,6-dihydro-12-aza-β-carboline derivative.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00476793
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