ISSN:
1573-8221
Keywords:
methindione
;
pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The pharmacokinetics of the new anticonvulsant, methindione, carbon-labeled in the carbonyl and N-methyl groups, was studied in experiments on rats. Methindione is quickly absorbed from the gastro-intestinal tract and passes easily through tissue barriers. The highest concentration of methindione in the brain is observed 15–30 min after administration. The metabolism of methindione and its elimination from the tissues take place rapidly. In most tissues only 6–23% of its maximal concentration still remains after administration of the drug. Metabolites of methindione, labeled in the carbonyl group, are excreted mainly through the kidneys, but metabolites labeled in the N-methyl group are excreted chiefly through the lungs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00804622
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