ISSN:
1662-0356
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Natural Sciences in General
,
Technology
Notes:
This paper presents two biomedical microsystems for blood cell counting, designed andbuilt through MultiMEMS Multi-Project Wafer (MPW) service and the microBUILDER Europeanproject. Dies mm in size, made of a micromachined glass-silicon-glass triple stack, host twonew kinds of multiple micro-counters, suitable to investigate the feasibility of blood cell differentialanalysis by means of Coulter principle in a monolithic lab-on-a-chip, which integrates amicrofluidic network, sensing metal electrodes and light-guiding structures. Within these devices,impedance method gains some innovative features, both from microsystem technology itself (lowconsumptions of chemicals, better analytical performances, low dead volumes in multifunctionalinterconnected networks, parallel high-throughput processing, low-cost mass production) and fromnew project solutions: self-aligning illumination allows to use compact external sources (i.e, LEDs)and requires no delicate optics. Different working set-ups (ranging from series with fixed controlvolume to parallel differential) can be achieved by adding only few external components. It isfinally possible to combine electrical and optical measurements, oriented to multi-featureclassification of cell sub-populations
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.57.55.pdf
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