ISSN:
1432-0886
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Breakage of human chromosomes was studied in vitro by treating leukocyte cultures for 8 hours with tretamine, tepa, hempa, hemel, and apholate. The aziridines tretamine, tepa, and apholate effectively induced aberrations; the dimethylamino compounds, hemel and hempa, induced few. Tretamine, the most effective compound, induced aberrations in 78% of the cells; hempa, the least effective, induced aberrations in 14%, even at a 1000-fold greater molar concentration. Abberations occurred in 6% of control cells. The gaps and breaks were induced randomly among cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00336199
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