ISSN:
1432-1041
Keywords:
Ciprofloxacin
;
quinolones
;
tissue penetration
;
bronchial mucosa
;
lung parenchyma
;
pleura
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have studied the concentrations of ciprofloxacin in serum, bronchial mucosa, lung parenchyma, and pleural tissue after a single intravenous dose of 200 mg in 20 patients subjected to lung surgery. The concentrations of ciprofloxacin in the tissues exceeded that in the serum by 3-fold to 7-fold: serum 0.6 μg·ml−1, bronchial mucosa 1.9 μg·g−1 lung parenchyma 3.4 μg·g−, and pleural tissue 1.7 μg·g−1. The achievable concentrations of ciprofloxacin in the tissues of the lower respiratory tract are above the MICs for most lung pathogens.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315290
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