ISSN:
1573-904X
Keywords:
fungicides
;
mechanism
;
electron transfer
;
oxidative stress
;
electrochemistry
;
iminium
;
quinones
;
metal complexes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Cyclic voltammetry data were obtained for several categories of fungicidal agents including quinones (akrobomycin, podosporin A), iminium ions and precursors (pyridazines, 15-azahomosterol, griseofulvin-4′-oxime), and metal derivatives of chelators (pyridine-2-aldehyde thiosemicarbazones). The reductions usually occurred in the range of −0.7 to +0.3 V. Reduction potentials provide information on the feasibility of electron transfer in vivo. Catalytic production of oxidative stress from redox cycling is a possible mode of action. Alternatively, there may be interference with normal electron transport chains.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015834431140
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