Publication Date:
2018-06-13
Description:
Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner, Published online: 12 June 2018; doi:10.1038/s41467-018-04757-w Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a key component of the Hippo pathway) between cytoplasm and nucleus in specific tumor suppressor contexts.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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