ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
We observed the cytotoxicity of human bone marrow stromal cells(hBMSCs) by microparticlesof bioactive glass with four particle groups(same chemical composition-45S5 butproduced by two different manufacturer and two different size groups). In vivo test using ratcalvaria were also carried out. The apoptosis rates of all small particle groups(10-20 ㎛) wereincreased than large(500-700 ㎛ or 200-900 ㎛) particle groups in any culture time and any amountof particles with statistical significance. In vivo study we observed pathologic signs such asmacrophages and foreign-body giant cells in rat calvaria by micro-particles of bioglass. Small(10-20 ㎛) sized particles induced foreign body reaction and bone resorption. There was proliferation ofmacrophages and cells in large number. But in large particle groups, only fibroblasts weresurrounding the particles. The micro-particles of bioglass induced apoptosis of hBMSC and foreignbody reaction in calvaria of rat, therefore micro-particles of bioglass may cause osteolysis if used inreplacement arthroplasty
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.193.pdf
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