ISSN:
1432-1041
Keywords:
cimetidine
;
tolbutamide
;
pharmacokinetic interaction
;
drug metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have investigated the influence of cimetidine on the disposition of tolbutamide in 7 healthy subjects, who received 250 mg tolbutamide daily for 4 days followed by the concomitant intake of cimetidine 400 mg twice daily for a further 4 days. Cimetidine had no effect on the disposition of tolbutamide, including the unbound hydroxylation clearance rate (324 ml·min−1, tolbutamide alone; 316 ml·min−1, tolbutamide plus cimetidine). The total urinary recovery of carboxy- and hydroxy-tolbutamide metabolites was 85.7±20.3% of the dose when tolbutamide was given alone and 78.9±14.3% when given with cimetidine. This lack of a pharmacokinetic interaction suggests selectivity of cimetidine-induced inhibition of Phase I drug oxidation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00606666
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