Publication Date:
2011-11-15
Description:
An efficient method for the synthesis of 2-aryl-2,3-dihydro-3-sulfanyl-1 H -isoindol-1-ones 1 via Pummerer -type cyclization of N -aryl-2-(sulfinylmethyl)benzamides 2 is described. Thus, treatment of these sulfinyl-benzamides 2 , easily prepared from 2-(bromomethyl)benzoates 3 in three steps, with Ac 2 O at ca. 100° resulted in the formation of the desired isoindolones 1 in generally good yields.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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