ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract Mature cross-bred dogs were acutely exposed to 1,1,1-trichloroethane, trichloroethylene, and toluene. The changes in hematologic parameters, during and after exposure, are reported. A marked but temporary decrease in leukocytes was noted 30 min after the initation of exposure; no changes were observed in erythrocyte counts, hematocrit values, or thrombocytes counts with all three solvents. The decrease in the amount of neutrophils was particularly prominent. Based upon leukocyte differential counts, all types of leukocytes snowed a decrease. The decrease in leukocyte counts was the largest with exposure to trichloroethylene, followed by 1,1,1-trichloroethane, and toluene, respectively. A dose-response relationship was noted between exposure concentrations and decreased leukocyte counts,i.e., 1,1,1-trichloroethane and toluene from 200 to 700 ppm; trichloroethylene from 0 to 700 ppm.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01056337
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