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  • 1
    Electronic Resource
    Electronic Resource
    TIP, a T-cell factor identified using high-throughput screening increases survival in a graft- versus -host disease model (2003)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 21 (2003), S. 302-307 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A coordinated effort combining bioinformatic tools with high-throughput cell-based screening assays was implemented to identify novel factors involved in T-cell biology. We generated a unique library of cDNAs encoding predicted secreted and transmembrane domain–containing ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt797
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  • 2
    Electronic Resource
    Electronic Resource
    Heterogeneity in the genetic basis of human complement C9 deficiency (1998)
    Springer
    Immunogenetics 48 (1998), S. 144-147 
    Details
    ISSN: 1432-1211
    Keywords: Key words Point mutations ; Hemolytic activity ; Ethnic origin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050415
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  • 3
    Electronic Resource
    Electronic Resource
    The human complement component C8B gene: structure and phylogenetic relationship (1993)
    Springer
    Human genetics 〈Berlin〉 92 (1993), S. 69-75 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The eighth component of human complement (C8) is a serum protein that consists of three chains (α, β and γ), encoded by three separate genes, viz., C8A, C8B, and C8G. In serum, the β-subunit is non-covalently bound to the disulfide-linked α-γ subunit. Using a full-length C8β cDNA probe, we isolated several clones from human genomic λ DNA libraries. Four λ clones covering the complete cDNA sequence were characterized by TaqI restriction mapping and were “shotgun” subcloned into M13. C8β-cDNA-positive clones were partially sequenced to characterize the 12 exons of the gene with sizes from 69 to 347 bp. All intron-exon junctions followed the GT-AG rule. By using polymerase chain reaction (PCR) primers located in the adjacent intron sequences, all 12 exons of the C8B gene could be amplified from genomic DNA. All fragments showed the expected sizes. The sizes of eight introns could be determined by using primer pairs that amplified two exons and the enclosed intron, and by restriction mapping. These analyses and the insert sizes of the genomic λ clones indicate that the C8B gene has a total size of approximately 40 kb. The polymorphic TaqI site of the C8B gene localized in intron 11 could be demonstrated by direct restriction fragment analysis of a PCR fragment containing exons 11 and 12, and the enclosed intron 11. Homology comparison of the C8B gene with C8A and C9 on the basis of the exon structure confirmed the ancestral relationship known from the protein level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216147
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  • 4
    Electronic Resource
    Electronic Resource
    The eighth component of human complement: molecular basis of C8A (C81) polymorphism (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 281-284 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using an exon-specific polymerase chain reaction (PCR) followed by direct DNA sequence analysis we have analyzed the polymorphism of the α-chain of the eighth component of human complement (C8) at the DNA level. We found that two common alleles, C8A*A and C8A*B, are characterized by the substitution of a single amino acid (Gln to Lys), which is caused by a point mutation of a single nucleotide (C to A) in exon 3 at position 187 of the mature C8α cDNA sequence. Based on this mutation, an allele-specific PCR was designed detecting the two alleles of C8A. We applied this method to type the C8A polymorphism using DNA samples from a Chinese Han population. The comparison with the data of protein typing of the same samples proved that the described method is efficient and reliable for the identification of C8A genotypes and may be valuable for further application in population studies and forensic science.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210407
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  • 5
    Electronic Resource
    Electronic Resource
    Assessment of left ventricular wall motion in normal and diseased hearts with velocity-encoded magnetic resonance (1994)
    Springer
    Magnetic resonance materials in physics, biology and medicine 2 (1994), S. 5-11 
    Details
    ISSN: 1352-8661
    Keywords: phase-contrast velocity encoding ; heart wall motion ; myocardial contraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract We present a noninvasive MR technique to assess the regional myocardial wall motion quantitatively. The method uses a phase-contrast sequence in conjunction with a masking program allowing for exact myocardial wall demarcation. Five healthy volunteers, aged 24 to 36 years, were studied to evaluate normal heart motion. These data served as a normal reference to myocardial motion patterns determined in five patients, aged 51 to 73 years, with known coronary artery disease induced wall motion abnormalities. Tangential motion in normal subjects showed a clockwise rotation at the cardiac base and counterclockwise rotation at the apex. The maximal radial velocity was 30.45±5.9 mm/s−1. Dyskinetic myocardial motion could be differentiated from normal ventricular motion: The number of hypomotile segments as well as hypokinetic and paradox phases determined with this method correlated well with patients' ejection fractions (r 2=0.95). This preliminary study demonstrates the ability of velocity-encoded MR to characterize myocardial motion and differentiate normal from dyskinetic heart motility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709794
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  • 6
    Electronic Resource
    Electronic Resource
    Mechanism of interfacial mass transfer in membrane transport (1968)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 14 (1968), S. 421-425 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Dialysis of binary aqueous solutions of several sugars through a cellophane membrane was studied in a stirred batch dialyzer. Sherwood numbers describing mass transfer resistance in the fluid adjacent to the membrane were determined as a function of the corresponding Reynolds and Schmidt numbers. The results establish a reproducible environment for membrane testing in which a known controllable and small interfacial resistance is placed in series with that of the membrane. The results are also shown to support, for this geometry, the postulation of a third power relationship between eddy diffusivity and dimensionless distance from the phase boundary as well as the Sherwood-Ryan nondimensionalization of this distance.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690140316
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  • 7
    Electronic Resource
    Electronic Resource
    Studies of intramembrane transport: A phenomenological approach (1968)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 14 (1968), S. 110-117 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The intramembrane transport properties of carbohydrates were investigated in cellophane. The experiments performed were the measurement of net volume transfer under a concentration and pressure gradient and the solute transfer due to a concentration difference together with the physical properties of the membrane. The matrix of phenomenological coefficients characteristic to the transport was established after the phase boundary contributions were extricated from the experimental transport data. These thermodynamic coefficients were then interpreted through the Spiegler-Kedem-Katchalsky frictional model.The analysis of the frictional coefficients clearly indicated the importance of solute-polymer interactions. The magnitude of solute-solvent frictional coefficients in the membrane were compared with the corresponding interactions in free solutions. Their differences were explained in terms of the interaction of the solute with the macromolecular network and were quantitatively expressed by introducing two reduced frictional coefficients. The tortuosity factor was shown to be related to these interactions and not a simple geometric property of the membrane. The temperature dependence of the frictional coefficients was established.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690140120
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  • 8
    Electronic Resource
    Electronic Resource
    Application of the Benedict-Webb-Rubin equation of state to argon (1966)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 12 (1966), S. 577-580 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The coefficients of the Benedict-Webb-Rubin equation of state have been developed for argon. By employing these coefficients, the volumetric behavior of argon has been predicted with an average deviation of 0.241% for five hundred ninety-seven smoothed and experimental data points in the superheated region.At temperatures below the critical, two sets of Co's, one for the liquid and one for the vapor, were needed to relate the vapor pressure to the densities of saturated argon. However, consistent fugacities for the saturated vapor and liquid argon could not be predicted with these Co values. Therefore, another set of Co's was developed by equating the pure component vapor and liquid fugacities along the vapor pressure curve. These values were used to test the applicability of the equation of state to predict derived thermodynamic properties.The original BWR expression for calculating isothermal pressure effects on enthalpy was modified to include explicitly the temperature dependence of the coefficient Co. Vapor-liquid equilibrium relations for the argon-nitrogen system predicted by the standard BWR procedure were compared with experimental data.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690120333
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  • 9
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    Reformation als Kommunikationsprozess (2021)
    Böhlau Verlag Köln
    Details
    Publication Date: 2023-08-08
    Description: Beim Hussitismus bzw. Utraquismus in Böhmen und der reformatorische Bewegung ab 1517 in Sachsen handelt es sich um zwei unterschiedliche Reformationen, jedoch mit einer Fülle von sachlichen und personalen Verbindungslinien. Diese rücken im vorliegenden Band erstmalig in einen gemeinsamen Fokus.»Wir sind alle Hussiten«, bekannte Martin Luther 1520 nach der Lektüre von Schriften des tschechischen Reformators Jan Hus, der gut einhundert Jahre zuvor als Ketzer verbrannt worden war. Die beiden Reformatoren verbinden, ebenso wie die von ihnen ausgehenden Erweckungs- und Erneuerungsbewegungen, viele Ähnlichkeiten, Übereinstimmungen und parallele Entwicklungsverläufe. Dennoch werden sie meist getrennt betrachtet. Der Sammelband analysiert Aspekte der Reformation in Böhmen und Sachsen und rückt so die beiden religiösen Brennpunkte in einen gemeinsamen Fokus. Methodisch wählen die Beiträgerinnen und Beiträger dabei einen kommunikationsgeschichtlichen Zugang.
    Keywords: Religion ; Christianity ; Protestant ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRC Christianity::HRCC Christian Churches & denominations::HRCC9 Protestantism & Protestant Churches
    Language: German
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    E-BOOK
  • 10
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    BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals (2019)
    National Academy of Sciences
    Details
    Publication Date: 2019-07-16
    Description: BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK, a multidomain BCL-2 family protein, is generally believed to be an adaptor protein similar to BAK and BAX, regulating the mitochondrial permeability transition during apoptosis. Here we report that BOK is a positive regulator of a key enzyme involved in uridine biosynthesis; namely, uridine monophosphate synthetase (UMPS). Our data suggest that BOK expression enhances UMPS activity, cell proliferation, and chemosensitivity. Genetic deletion of Bok results in chemoresistance to 5-fluorouracil (5-FU) in different cell lines and in mice. Conversely, cancer cells and primary tissues that acquire resistance to 5-FU down-regulate BOK expression. Furthermore, we also provide evidence for a role for BOK in nucleotide metabolism and cell cycle regulation. Our results have implications in developing BOK as a biomarker for 5-FU resistance and have the potential for the development of BOK-mimetics for sensitizing 5-FU-resistant cancers.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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