ISSN:
1573-3904
Keywords:
Aβ 1-42 synthesis
;
Fmoc-aminoacyl fluorides
;
RP HPLC
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Fmoc-amino acid fluorides are highly efficient coupling agents for solution and solid-phase peptide synthesis and this property was used advantageously for the manual solid-phase assembly of the Alzheimer's Aβ 1–42 peptide [Milton et al., In Marshak, D. (Ed.) Techniques in Protein Chemistry, Vol. VIII, Academic Press, Orlando, FL, 1997, pp. 865–873]. Further studies comparing this methodology in the preparation of Aβ 1–42 peptide analogs employing a fully automated continuous-flow peptide synthesizer are reported.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008858416745
Permalink