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  • 1
    Publication Date: 2005-11-16
    Description: Recombinant human factor VIIa (rhFVIIa) has recently been used off label as a hemostatic agent for a variety of congenital and acquired coagulopathies. We report a case of bleeding from an acquired factor V (FV) inhibitor after exposure to bovine thrombin that failed to respond to rhFVIIa concentrate. A 63 y/o male presented with syncope followed by hematuria 4 weeks after spinal fusion surgery where bovine thrombin was used to seal a dural leak. His initial PT was 78, APTT 〉90, INR 7.0, H/H 7.3/20.9, FII 0.46 U/ml, FV 90. He received rhFVIIa again at 4.8 mg and continued to bleed with no changes in coagulation profile or bleeding. He then received 9.6 mg of rhFVIIa with no change. He continued on IVIG and IV methylprednisolone but continued to bleed with PT 〉90, INR not calculable, and APTT 〉90. He was switched to oral prednisone, plasmapheresis (PP) initiated, and the PT post-PP was 72, INR 6.5, APTT 〉90. His coagulation parameters returned to pre-PP levels. FV level was then undetectable and the FII level was 90. He had aggressive volume resuscitation and PP was reinitiated. He was restarted on prednisone and cyclophosphamide was initiated. No bleeding source was identified, no rhFVIIa was given, his condition stabilized, and he was discharged. At 12 weeks post-operatively, his FV level increased from
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 2
    Publication Date: 2006-11-16
    Description: Pulmonary embolism (PE) is a major cause of preventable hospital deaths. Little is known about PE in the setting of pneumonia, as symptoms and signs of PE and pneumonia overlap, confounding diagnosis. With infrequent thromboprophylaxis, PE continues to be a major public health problem. In order to determine the incidence and characteristics of PE in patients with pneumonia, we analyzed statewide discharge data, 1997–2001, collected by the Pennsylvania Health Care Cost Containment Council (PHC4). The analysis included all PE discharges with ICD-9 codes 415.11 and 415.19, excluding pregnant patients and all second or later PE admissions. Infectious disease diagnoses were enumerated by ICD-9 codes, including 030–041, 042, 790.7, 996–998; pneumonia by ICD-9 codes 480–483. 485–487, and 996–998; and diagnostic procedures by revenue code 352 for computerized tomographic (CT), including spiral CT scans. Severity of illness was determined by MediQual Altas Admission Severity Categories. Of 33,036 total PE discharges (all-PE) from Pennsylvania hospital discharges 1997–2001, 5,757 (16.8%) had infection, more than half of which, 3,543 (52.3%), were due to pneumonia (pneumonia-PE). There was a marginal increase in the incidence of pneumonia-PE during this period, 615 (10.3%) in 1997 to 839 (10.5%), p〉0.05. Those with pneumonia-PE were typically Caucasian, 77.3%, p
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Location Call Number Expected Availability
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