ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In the present study, superparamagnetic maltotrionic acid-coated magnetite nanoparticles(MAM) were surface modified with doxorubicin (DOX) and RGD peptide to improve theirintracellular uptake, ability to target tumor cells and antitumer effect. RGD was added to the distalend of MAM aiming to construct an enhanced tumor targeting delivery system. To test its targetingeffect, DOX, a widely used anticancer drug, was immobilized on the RGD-modified magnetitenanoparticles. DOX-coated magnetite nanoparticles were also prepared as a control. KB cell cultureexperiment showed that both DOX-modified nanoparticles and DOX-RGD peptide-modifiedmagnetite nanoparticles (DRMAM) were internalized into the cells. But the uptake amount ofDRMAMs was higher than that of DOX-modified nanoparticles. This result indicates thatDRMAMs have a great potential to be used as contrast agent and antitumor medicine
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.793.pdf
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