ISSN:
1572-8854
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geosciences
,
Physics
Notes:
Abstract The molecular structures of three dimethiodide bisquaternary aza steroids, determined crystallographically, are reported. The compounds are (i) 17a-methyl-3β-pyrrolidino-17a-aza-d-homo-5-androstene dimethiodide (HS310, or chandonium iodide), (ii) 4,17a-dimethyl-4, 17a-diaza-d-homo-5α-androstane dimethiodide (HS342), and (iii) 4-methyl-17β-dimethylamino-4-aza-5α-androstane dimethiodide (HS467). RingB in HS310 is a half-chair and ringD in HS467 is a distorted envelope. All other rings in the steroid skeletons of the three molecules are in the chair conformation, and all rings aretrans-connected. All three molecules are known to exhibit competitive neuromuscular blocking activity, each with different potency. This is discussed in relation to the observed inter-onium N+ ⋯ N+ distances and other features of molecular geometry of importance in drug design.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01209551
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