Publication Date:
2008-01-12
Description:
Substantial evidence exists that many tumors can be specifically recognized by CD8+ T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8+ T cell response that is reactive to a peptide derived from histone H4. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice. Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savage, Peter A -- Vosseller, Keith -- Kang, Chulho -- Larimore, Kevin -- Riedel, Elyn -- Wojnoonski, Kathleen -- Jungbluth, Achim A -- Allison, James P -- New York, N.Y. -- Science. 2008 Jan 11;319(5860):215-20. doi: 10.1126/science.1148886.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18187659" target="_blank"〉PubMed〈/a〉
Keywords:
Adenocarcinoma/*immunology
;
Adoptive Transfer
;
Animals
;
Antigen Presentation
;
Antigens, Neoplasm/*immunology
;
Autoantigens/*immunology
;
CD8-Positive T-Lymphocytes/*immunology
;
Cell Line
;
Epitopes, T-Lymphocyte/immunology
;
Histones/*immunology
;
Hybridomas
;
Lymphocytes, Tumor-Infiltrating/*immunology
;
Male
;
Mice
;
Mice, Transgenic
;
Peptide Fragments/immunology
;
Prostatic Neoplasms/*immunology
;
Receptors, Antigen, T-Cell, alpha-beta/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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