Publication Date:
1983-03-04
Description:
The pineal gland hormone melatonin may play a role in synchronization of rat circadian rhythms. Free-running activity rhythms of the rat were entrained by a daily melatonin injection, with entrainment occurring when the onset of activity coincided with the time of daily injections. When injections were stopped, activity rhythms became free-running again. Thus in pharmacological experiments, the time of day of melatonin administration is crucial.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Redman, J -- Armstrong, S -- Ng, K T -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823571" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Circadian Rhythm/*drug effects
;
Drug Administration Schedule
;
Male
;
Melatonin/pharmacology/*physiology
;
Motor Activity/*physiology
;
Pineal Gland/*physiology
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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