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  • 1
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    Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2 (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-11-02
    Description: beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biragyn, Arya -- Ruffini, Pier Adelchi -- Leifer, Cynthia A -- Klyushnenkova, Elena -- Shakhov, Alexander -- Chertov, Oleg -- Shirakawa, Aiko K -- Farber, Joshua M -- Segal, David M -- Oppenheim, Joost J -- Kwak, Larry W -- N0L-CO-12400/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1025-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA. arya@mail.ncifcrf.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411706" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/immunology ; Cancer Vaccines/immunology ; Cell Line ; Cytokines/biosynthesis ; Dendritic Cells/*immunology ; *Drosophila Proteins ; Female ; Humans ; Interferon-alpha/physiology ; Ligands ; Lipopolysaccharides/immunology/pharmacology ; Lymphocyte Culture Test, Mixed ; Membrane Glycoproteins/genetics/*physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Neoplasms/immunology/therapy ; Receptors, CCR6 ; Receptors, Cell Surface/genetics/*physiology ; Receptors, Chemokine/metabolism ; Recombinant Fusion Proteins/pharmacology ; Signal Transduction ; Toll-Like Receptor 4 ; Toll-Like Receptors ; Transfection ; beta-Defensins/pharmacology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-12
    Description: Concentrations of acetyl-coenzyme A and nicotinamide adenine dinucleotide (NAD(+)) affect histone acetylation and thereby couple cellular metabolic status and transcriptional regulation. We report that the ketone body d-beta-hydroxybutyrate (betaOHB) is an endogenous and specific inhibitor of class I histone deacetylases (HDACs). Administration of exogenous betaOHB, or fasting or calorie restriction, two conditions associated with increased betaOHB abundance, all increased global histone acetylation in mouse tissues. Inhibition of HDAC by betaOHB was correlated with global changes in transcription, including that of the genes encoding oxidative stress resistance factors FOXO3A and MT2. Treatment of cells with betaOHB increased histone acetylation at the Foxo3a and Mt2 promoters, and both genes were activated by selective depletion of HDAC1 and HDAC2. Consistent with increased FOXO3A and MT2 activity, treatment of mice with betaOHB conferred substantial protection against oxidative stress.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735349/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735349/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimazu, Tadahiro -- Hirschey, Matthew D -- Newman, John -- He, Wenjuan -- Shirakawa, Kotaro -- Le Moan, Natacha -- Grueter, Carrie A -- Lim, Hyungwook -- Saunders, Laura R -- Stevens, Robert D -- Newgard, Christopher B -- Farese, Robert V Jr -- de Cabo, Rafael -- Ulrich, Scott -- Akassoglou, Katerina -- Verdin, Eric -- P30 DK026743/DK/NIDDK NIH HHS/ -- P30 DK063720/DK/NIDDK NIH HHS/ -- R01 DK056084/DK/NIDDK NIH HHS/ -- T32 AG000212/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):211-4. doi: 10.1126/science.1227166. Epub 2012 Dec 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23223453" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Hydroxybutyric Acid/blood/*metabolism/pharmacology ; Acetylation ; Animals ; Caloric Restriction ; Catalase/metabolism ; Fasting ; Forkhead Transcription Factors/genetics ; HEK293 Cells ; Histone Deacetylase Inhibitors/blood/*metabolism/pharmacology ; Histone Deacetylases/genetics/*metabolism ; Histones/metabolism ; Humans ; Kidney/drug effects/*metabolism ; Lipid Peroxidation ; Metallothionein/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; *Oxidative Stress/genetics ; Promoter Regions, Genetic ; RNA, Small Interfering ; Superoxide Dismutase/metabolism ; Transcription, Genetic ; Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Pole and global shape of 25143 Itokawa (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-06-03
    Description: The locations of the pole and rotation axis of asteroid 25143 Itokawa were derived from Asteroid Multiband Imaging Camera data on the Hayabusa spacecraft. The retrograde pole orientation had a right ascension of 90.53 degrees and a declination of -66.30 degrees (52000 equinox) or equivalently 128.5 degrees and -89.66 degrees in ecliptic coordinates with a 3.9 degrees margin of error. The surface area is 0.393 square kilometers, the volume is 0.018378 cubic kilometers with a 5% margin of error, and the three axis lengths are 535 meters by 294 meters by 209 meters. The global Itokawa revealed a boomerang-shaped appearance composed of two distinct parts with partly faceted regions and a constricted ring structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Demura, Hirohide -- Kobayashi, Shingo -- Nemoto, Etsuko -- Matsumoto, Naoya -- Furuya, Motohiro -- Yukishita, Akira -- Muranaka, Noboru -- Morita, Hideo -- Shirakawa, Ken -- Maruya, Makoto -- Ohyama, Hiroshi -- Uo, Masashi -- Kubota, Takashi -- Hashimoto, Tatsuaki -- Kawaguchi, Jun'ichiro -- Fujiwara, Akira -- Saito, Jun -- Sasaki, Sho -- Miyamoto, Hideaki -- Hirata, Naru -- New York, N.Y. -- Science. 2006 Jun 2;312(5778):1347-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computer Software, University of Aizu, Ikki-machi, Aizu-Wakamatsu City, Fukushima 965-8580, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16741112" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Electronic Resource
    Electronic Resource
    Magnetic and magneto-optical properties of perpendicular magnetic 3d transition-metal fluoride films (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 3253-3255 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Optically transparent, ferromagnetic films of Fe-F, Co-F, and Ni-F have been prepared by rf sputtering from powder-compacted targets of FeF3, CoF3, and NiF2. The films are amorphous, containing a small amount of crystalline fluoride. Some films showed perpendicular magnetic anisotropy, high coercivity (700–1500 Oe), and fairly high remanence ratio (0.23–0.7). Faraday rotation coefficients of 104 deg/cm at a wavelength of 633 nm were found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.338898
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  • 5
    Electronic Resource
    Electronic Resource
    Magneto-optical properties of Fe-B-F films (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 3250-3252 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Films have been preprared by sputtering over a wide range of compositions in the Fe-B-F system. Fluorine was supplied by rf sputtering from an FeF3 target, and Fe-B by dc sputtering from arc-melted targets. Most of the samples were amorphous, although some contained a relatively small fraction of crystalline FeF2. The films were ferromagnetic, with Curie temperatures above room temperature and with room-temperature saturation magnetizations of 60 to 150 emu/g. Large Faraday coefficients, up to 105 deg/cm at 633 nm and fairly large Kerr rotations were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.338925
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  • 6
    Electronic Resource
    Electronic Resource
    Magnetic properties of MnAlGe and related compounds (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 3255-3257 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: MnAlGe is a ferromagnet with a unique crystal structure including two-dimensional arrays of Mn atoms in it. In order to find the magnetic properties characteristic of this structure, magnetic and electric measurements were made for Mn0.9M0.1AlGe (M:Mn, Cr, Fe) and MnGaGe. It has been found that the susceptibility above the Curie temperature (TC) does not obey the Curie–Weiss law over the very wide temperature range. Obtained susceptibility vs temperature curves are well expressed by a formula χg=C/(T−θa)γ with a composition dependent parameter γ ranging from about 1.3 to 1.5. In MnAlGe the formula with γ=1.49 holds in the whole temperature range from just above TC (=503 K) to Tt (=853 K, a temperature of solid-state transition). The Curie temperature of Mn1−xMxAlGe(x≤0.2) varies monotonically when they are plotted against the averaged number of d electrons per transition-metal atom. The temperature dependencies of saturation magnetization and electric resistivity were also measured for these specimens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.335116
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  • 7
    Electronic Resource
    Electronic Resource
    Structure of the α-cyclodextrin (α-CD) inclusion complex with the potassium salt of γ-aminobutyric acid (GABA) (1981)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 37 (1981), S. 445-447 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740881003233
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  • 8
    Electronic Resource
    Electronic Resource
    Acceleration of proton exchange between octanol and water by 2,4-dinitrophenol determined by ^1H-NMR spectrometry a new model for proton transfer in a hydrophobic environment
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Bioenergetics 725 (1983), S. 254-260 
    Details
    ISSN: 0005-2728
    Keywords: 2,4-Dinitrophenol ; NMR ; Oxidative phosphorylation ; Proton transfer ; Uncoupler
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2728(83)90198-6
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  • 9
    Electronic Resource
    Electronic Resource
    Dynamic response of an orthotropic cylindrical shell to rapid heating
    Amsterdam : Elsevier
    Journal of Sound and Vibration 83 (1982), S. 27-35 
    Details
    ISSN: 0022-460X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0022-460X(82)80073-4
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  • 10
    Electronic Resource
    Electronic Resource
    The orbit of the Eta Aquarid meteor stream
    Amsterdam : Elsevier
    Planetary and Space Science 42 (1994), S. 113-116 
    Details
    ISSN: 0032-0633
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0032-0633(94)90019-1
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